AngIV Analog Dihexa Rescues Cognitive Impairment and Recovers Memory in the APP PS1 Mouse via the PI3K AKT Signaling Pathway Dihexa (also known as PNB 0408) is an experimental small molecule derived from angiotensin IV. It was engineered to cross the bloodbrain barrier and has shown synaptogenic effects in preclinical models. The often quoted D I H E X A is having a moment right now and I get why. When something gets labeled as brain repair or synapse growth, it spreads FAST especially in communities Alzheimer's disease may damage the brain in two phases National Institutes of Health (NIH)