Glutanex Injection 1200mg by Nexus Pharma 10 Session ApniCare.Pk Paracetamol is one of the most commonly used analgesic and antipyretic drugs. The gamma glutamyl pathway after glutathione depletion due to Download Scientific Diagram Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors.