Tylenol Avoid or Not to Avoid? Acetaminophen (Tylenol) can deplete glutathione, your body's most important detox antioxidant. This matters even more if your child has an MTHFR gene mutation, which PARACETAMOL DEPLETES GLUTATHIONE Natural Healing Centre Acetaminophen at low doses depletes airway glutathione and alters respiratory reflex responses Smith 2013 The FASEB Journal Wiley Online Library Acetaminophen causes neurodevelopmental injury in susceptible babies and children: no valid rationale for controversy