Recurrent Pyroglutamic Acidosis Related to Therapeutic Acetaminophen ScienceDirect Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: PDF] Evidence that Increased Acetaminophen use in Genetically Vulnerable Children Appears to be a Major Cause of the Epidemics of Autism, Attention Deficit with Hyperactivity, and Asthma Semantic Scholar Frontiers Paracetamol Induced Glutathione Consumption: Is There a Link With Severe COVID 19 Illness?