Acetaminophen Toxicity: How Genetic Susceptibility Combines with Environmental Factors Could Tylenol be making your child's health worse? Acetaminophen is widely used for pain and fever relief, but research suggests it depletes glutathione, a powerful antioxidant essential for immune function, Glutathione S transferase genes and asthma phenotypes: a Human Genome Epidemiology (HuGE) systematic review and meta analysis in Nebulized Glutathione Treatment for Lung Health.