What Foods to Avoid When Taking Glutathione the biostation The Truth About Paracetamol and Glutathione Levels Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Did you know that drugs like Tylenol and ibuprofen deplete the body's chief detoxifier, GLUTATHIONE? This is a BIG DEAL. Glutathione is essential not only for detox but also IMMUNE function,