A 48 hour fast can turn standard Paracetamol into acute liver failure. Fasting depletes Glutathione, leaving the liver defenseless against toxic NAPQI. Review the latest guidelines on BMJ Best Practice: https: bestpractice.bmj.com topics en us 1010 PARACETAMOL DEPLETES GLUTATHIONE Natural Healing Centre Perinatal exposure to paracetamol: Dose and sex dependent effects in behaviour and brain's oxidative stress markers in progeny ScienceDirect Sulfate conjugation may be the key to hepatotoxicity in paracetamol overdose Li 2021 British Journal of Clinical Pharmacology Wiley Online Library
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