L Carnitine intake and high trimethylamine N oxide plasma levels correlate with low aortic lesions in ApoE transgenic mice expressing CETP Atherosclerosis Characterization of TMAO productivity from carnitine challenge facilitates personalized nutrition and microbiome signatures discovery Microbiome Springer Nature Link JCI Insight Aorta and liver generated TMAO enhances trained immunity for increased inflammation via ER stress mitochondrial ROS glycolysis pathways O Acetyl L carnitine hydrochloride