Leucovorin (Folinic Acid) The Rescue Drug! Pearl:Leucovorin (Folinic Acid) is Methotrexate's antidote. It is the reduced form of folate that can bypass the enzyme dihydrofolate reductase (which Methotrexate inhibits). Application: It Frontiers Nitazoxanide mitigates methotrexate hepatotoxicity in rats: role in inhibiting apoptosis and regulating endoplasmic reticulum stress Attenuation of methotrexate induced hepatotoxicity by epigallocatechin 3 gallate: Drug and Chemical Toxicology: Vol 46, No 4 Molecular toxicity of methotrexate in rheumatoid arthritis treatment: A novel perspective and therapeutic implications ScienceDirect
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glutathione and methotrexate Glucarpi-CAP: A Retrospective Case Series of 1000-Unit Glucarpidase Dosing for Methotrexate Rescue